Quantitative magnetic resonance cholangiopancreatography metrics improve prognostication in primary sclerosing cholangitis
JHEP Reports, 2026
Abstract
Background & Aims
Quantitative magnetic resonance cholangiopancreatography (MRCP) metrics showed prognostic potential in primary sclerosing cholangitis (PSC). This international multicentre study aimed to provide the first reference range for quantitative metrics in PSC and assess the additional role of quantitative metrics in prognostication.
Methods
Quantified MRCP (MRCP+) and clinical data were collected from six European tertiary referral and transplantation centres. A healthy cohort was available for comparison. Least Absolute Shrinkage and Selection Operator analysis was used to derive variables for a prognostic model in a derivation cohort, referred to as the quantitative MRCP augmented Amsterdam–Oxford Model (qmAOM). Composite endpoint included PSC-related mortality, transplantation, or hepatic decompensation, without hepatic decompensation as secondary endpoint. Performance was assessed in the validation cohort, expressed as C-statistic (95% CI), and compared with the Amsterdam–Oxford Model (AOM), Mayo Risk Score and MRCP+, bilirubin, and aspartate aminotransferase (M+BA) scores.
Results
In total, 457 participants with PSC were included for the reference range, which differed significantly in comparison with the healthy controls. Prognostic analysis included 320 participants. qmAOM included: age at PSC diagnosis, inflammatory bowel disease presence, serum alkaline phosphatase, aspartate aminotransferase, albumin, bilirubin, platelets, number of strictures, number of ducts with strictures or dilatations and proportion of 3–5-mm ducts. qmAOM, AOM, and M+BA demonstrated 0.83 (0.77–0.93), 0.79 (0.68–0.91), and 0.65 (0.64-0.84), respectively. In secondary endpoint analysis, qmAOM and Mayo Risk Score demonstrated 0.84 (0.76–0.86) and 0.74 (0.68–0.81), respectively. In bootstrap analysis using the entire prognostic cohort, qmAOM performed significantly better than AOM and M+BA (0.82; 0.75; 0.70, respectively; p <0.001).
Conclusions
This study provides the first reference range of quantitative metrics in PSC and indicates that quantitative biliary metrics improve discriminative performance in event-free survival in PSC.
